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Ncor1 Gene Detail
Summary
  • Symbol
    Ncor1
  • Name
    nuclear receptor co-repressor 1
  • Synonyms
    5730405M06Rik, A230020K14Rik, mKIAA1047, N-CoR, Rxrip13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349717
    NCBI Gene: 20185
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62207132-62348200 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.08 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2837 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349717
 protein coding gene Chr11:62207132-62349367 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018453
 protein coding gene Chr11:62336514-62499767 (-)
A/J MGP_AJ_G0018422
 protein coding gene Chr11:60041258-60189503 (-)
AKR/J MGP_AKRJ_G0018392
 protein coding gene Chr11:61895333-62044166 (-)
BALB/cJ MGP_BALBcJ_G0018393
 protein coding gene Chr11:60327244-60471375 (-)
C3H/HeJ MGP_C3HHeJ_G0018206
 protein coding gene Chr11:61866545-62025267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018845
 protein coding gene Chr11:64302508-64460841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016491
 protein coding gene Chr11:57141351-57284365 (-)
CAST/EiJ MGP_CASTEiJ_G0017763
 protein coding gene Chr11:62006016-62153356 (-)
CBA/J MGP_CBAJ_G0018180
 protein coding gene Chr11:67085288-67263043 (-)
DBA/2J MGP_DBA2J_G0018289
 protein coding gene Chr11:59594107-59739305 (-)
FVB/NJ MGP_FVBNJ_G0018280
 protein coding gene Chr11:59272770-59415521 (-)
LP/J MGP_LPJ_G0018362
 protein coding gene Chr11:62895063-63047646 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018304
 protein coding gene Chr11:68078908-68239659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018886
 protein coding gene Chr11:62042585-62194711 (-)
PWK/PhJ MGP_PWKPhJ_G0017536
 protein coding gene Chr11:60215123-60362412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017326
 protein coding gene Chr11:61884544-62037652 (-)
WSB/EiJ MGP_WSBEiJ_G0017815
 protein coding gene Chr11:61644620-61795980 (-)



Homology
more
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
  • Synonyms
    hN-CoR, N-CoR, N-CoR1, PPP1R109, TRAC1
  • Links
    NCBI Gene ID: 9611
    neXtProt AC: NX_O75376
    UniProt: O75376

  • Chr Location
    17p12-p11.2; chr17:16029065-16218185 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    174
  • cDNA Data
    29
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20185 NCBI Gene Model | MGI Sequence Detail 141069 C57BL/6J ±  kb
    transcript NM_001252313 RefSeq | MGI Sequence Detail 8852 C57BL/6  
    polypeptide Q60974 UniProt | EBI | MGI Sequence Detail 2453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 34
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24052, MGI:103184, MGI:2441784, MGI:2444535
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 16
      Gene Ontology 45
      Phenotypes 74
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353879 Ritter MJ, et al., Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport. Endocrinology. 2024 Jul 26;165(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory